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Select Publications
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Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A,. Billia., F., Firpo, E., Hui, C.C., Roberts, J., Rossant, J., and Mak, T.W. (1996). The tumor suppressor Brca1 is required for embryonic cellular proliferation in the mouse. Cell, 85: 1009-1023.
McPherson, J. P., Lemmers, B., Chahwan, R., Pamidi, A., Migon, E., Matysiak-Zablocki, E., Moynahan, M. E., Essers, J., Hanada, K., Poonepalli, A., Sanchez-Sweatman, O., Khokha, R., Kanaar, R., Jasin, M., Hande, M. P., and Hakem, R. (2004). Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science, 304: 1822-1826.
McPherson, J. P., Lemmers, B., Hirao, A., Hakem, A., Abraham, J., Migon, E., Matysiak-Zablocki, E., Tamblyn, L., Sanchez-Sweatman, O., Khokha, R., Squire, J., Hande, M. P., Mak, T. W., and Hakem, R. (2004). Collaboration of Brca1 and Chk2 in tumorigenesis. Genes & Dev, 18: 1144-1153.
Salmena, L. and Hakem, R. (2005). Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. The Journal of Experimental Medicine, 202: 727-732.
Li, L., Halaby, M. J., Hakem, A., Cardoso, R., El Ghamrasni, S., Harding, S., Chan, N., Bristow, R., Sanchez, O., Durocher, D., Hakem, R. (2010). Rnf8 deficiency impairs class switch recombination, spermatogenesis, genomic integrity and predisposes for cancer. The Journal of Experimental Medicine. 207:983-97
Bohgaki, T., Bohgaki, M., Cardoso, R., Panier, S., Stewart, G.S., Sanchez, O., Durocher, D., Hakem, A. and Hakem, R. (2011). Genomic instability, defective spermatogenesis, immunodeficiency and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. April; 7(4): e1001381
Hakem, A., Bohgaki, M., Lemmers, B., Tai, E., Leonardo Salmena, L., Elzbieta Matysiak-Zablocki, E., Bähr, W. I. L., Karaskova, J., Boutros, P, Sheng, Y., Arrowsmith, C., Chesi, M., Bergsagel P. L., Perez-Ordonez, B., Squire, J., Jurisica, I., Penn, L., Sanchez, O., Benchimol, S. & Hakem, R. (2011). Role of Pirh2 in Mediating the regulation of p53 and c-Myc. PLoS Genet. Nov;7(11): e1002360.
Bohgaki, T., Salmena, L., Matysiak-Zablocki, E., Bohgaki, M., Sanchez, O., Strasser, A., Hakem, A. and Hakem, R. (2011). Caspase-8 Inactivation in T-cells Increases Necroptosis and Suppresses Autoimmunity Associated with Bim Deficiency. The Journal of Cell Biology. 195(2):277-91.
Hakem, A., El Ghamrasni, S., Maire, G., Lemmers, B., Salmena, L., Karaskova, J., Perez-Ordonez, B., Sanchez, O., Squire, J. and Hakem, R. (2012). Role of Casp8 in Cytokinesis, Genomic Integrity and Cancer. Blood. 119, p3495.
Halaby MJ, Hakem A, Li L, El Ghamrasni S, Venkatesan S, Hande P, Sanchez O and Hakem R. Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. (2013). PLoS Genet. 2013;9(1):e1003259.
Bohgaki M, Bohgaki M, Srikumar T, Maire G, Panier S, Stewart G, Raught R, Hakem A and Hakem R. RNF168 Ubiquitylates 53BP1 and Controls Its Responses to DNA Double-Strand Breaks. (2013). PNAS 110(52):20982-7.
El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A. Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. (2015). Oncogene. 34(14):1780-9.
El Ghamrasni S, Cardoso R, Bjerregaard V, Liu Y, Venkatesan S, Hande MP, Henderson J, Hickson I, Sanchez O, Hakem A and Hakem R. Rad54 and Mus81 cooperation promotes DNA damage repair and restrains genomic instability and chromosome missegregation. (2016). Oncogene. 35(37):4836-45
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Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A and Hakem R. RNF168 and USP10 regulate topoisomerase IIa function via opposing effects on its ubiquitylation. (2016) Nat. Commun. 7:12638
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Li, L., Guturi, K. K. N., Gautreau, B., Patel, P. S., Saad, A., Morii, M., Mateo, F., Palomero, L., Barbour, H., Gomez, A., Ng, D., Kotlyar, M., Pastrello, C., Jackson, H. W., Khokha, R., Jurisica, I., Affar, E. B., Raught, B., Sanchez, O., … Hakem, R. (2018). Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. The Journal of Clinical Investigation, 128(10), 4525–4542. https://doi.org/10.1172/JCI120401
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Patel, P. S., Abraham, K. J., Guturi, K. K. N., Halaby, M.-J., Khan, Z., Palomero, L., Ho, B., Duan, S., St-Germain, J., Algouneh, A., Mateo, F., El Ghamrasni, S., Barbour, H., Barnes, D. R., Beesley, J., Sanchez, O., Berman, H. K., Brown, G. W., El Bachir Affar, … Hakem, R. (2021). RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Journal of Clinical Investigation, 131(3), e140105. https://doi.org/10.1172/JCI140105
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Patel, P.S., Algouneh, A. & Hakem, R. Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand. Oncogene (2021). https://doi.org/10.1038/s41388-021-01744-2 (PSP and AA contributed equally)